folate level greater than 20

Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. 12 (8):e0182099. WebFolate-deficiency anemia in pregnancy may cause a neural tube defect. The authors of a 2012 meta-analysis of 19 randomized controlled trials that included 47,921 participants concluded that B-vitamin supplementation has no effect on the risk of cardiovascular disease, myocardial infarction, coronary heart disease, or cardiovascular death, although it does reduce the risk of stroke by 12% [86]. JAMA. Results below 4 mcg/L are suggestive of folate deficiency. Persons with lower or excess folate status are both at greater risk of mortality. Results of 2-year vitamin B treatment on cognitive performance: secondary data from an RCT. Folate deficiency has been associated with the presence of depression, 1 may hinder response to antidepressants, 1,2 and may contribute to relapse of depression. Am J Clin Nutr 2007;85:285S-8S. 2010 Jan. 91(1):231-7. J Natl Cancer Inst 1993;85:875-84. [, Gougeon L, Payette H, Morais JA, et al. WebHer first test at 8, the B-12 was 1097 (180-914 scale), folate was 18.4 (normal: 3.0 ng/ml). Am J Clin Nutr 2011;94:303S-12S. [QxMD MEDLINE Link]. The University of Maryland Medical Center states that intestinal blind loop syndrome -- also known as stasis syndrome or stagnant loop syndrome -- occurs when a segment of your small intestine becomes bypassed and cut off from the usual flow of food and digestive juices. WebFolic acid helps form red blood cells and produce DNA that stores genetic codes. McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM. The cutoff is based on consensus and was derived from the US NHANES III data.(4). Without enough oxygen, your body cant work as well as it should. Am J Clin Nutr 2008;88:1602-10. Some years ago I reported 2 boys who had repeated episodes of acute febrile lymphadenopathy. Elsevier; 2018:chap 37. [QxMD MEDLINE Link]. Last Updated 01 March, 2023. Compared with placebo, treatment with B vitamins significantly decreased homocysteine levels but did not reduce the risk of death from cardiovascular causes or myocardial infarction. He had headaches, nausea and fatigue. Am J Clin Nutr 2012;96:80-9. [, Morris MS, Fava M, Jacques PF, et al. By statistical definition, 2-5% of healthy individuals will have a serum folate level of less than 2.5 ng/mL; hence, the serum folate level cannot be used alone to establish the diagnosis of folate deficiency. Int J Clin Pract 2012;66:544-51. %PDF-1.6 % George L, Mills JL, Johansson AL, et al: Plasma folate levels and risk of spontaneous abortion. Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS. 11th ed. Total folate and unmetabolized folic acid in the breast milk of a cross-section of Canadian women. Its an essential vitamin, meaning that our bodies cant make it themselves, and its vital for production of new cells (aka the building blocks of life). Because of its role in the synthesis of DNA and other critical cell components, folate is especially important during phases of rapid cell growth [135]. However, some people are at risk for folate toxicity from dietary supplements, and fortified foods. Pieroth R, Paver S, Day S, Lammersfeld C. Folate and Its Impact on Cancer Risk. People with alcohol use disorder My 8 year old Son and myself have high folate levels in our blood but it has been ignored by Dr's. 2005 Feb. 118(2):161-7. Present Knowledge in Nutrition. 0000013590 00000 n 0000087065 00000 n Thiamin was discontinued and three weeks later he had another episode of febrile lymphadenopathy. Results from clinical trials involving folic acid supplementation have been mixed. 0000019166 00000 n This is when the brain or spinal cord doesnt develop normally. 0000193598 00000 n I am a 76 year old male. All rights reserved. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Fairbanks VF, Klee GG: Biochemical aspects of hematology. Stover PJ. More research is needed to fully understand how dietary folate and supplemental folic acid affect cancer risk and whether their effects differ by timing of exposure. [QxMD MEDLINE Link]. Common dietary sources of folate include cereals, leafy green vegetables, asparagus, legumes and organ meat. Elevated level is caused when cells are not methylating correctly. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. J Am Coll Cardiol. High B12 and high folic acid are signs of hemochromatosis. The researchers found no association between B-vitamin supplementation and cancer outcomes. This test is also needed for pregnant women and who are planning to get pregnant. This is classic in neurological involvement, we see it all the time in ALS, MS, Parkinson's, Autism, Post Stroke My 8 year old son also had high levels of folate in his blood and was allergic to milk. In a substudy of 300 participants, the supplementation also had no significant effects on biomarkers of vascular inflammation [91], but it did lower homocysteine levels by a mean of 18.5% [89]. J Obstet Gynaecol Can 2007;29:1003-13. He was treated with megadose thiamin and the concentrations of folate and B 12 fell into the normal range. In any case, having an elevated folate level is not dangerous, a sign of any disease, or a cause of any health problems. Medical experts agree that the normal range of folic acid in the blood is between 2.7 and 17.0 nanogram/milliliter. Association of folic acid supplementation during pregnancy with the risk of autistic traits in children exposed to antiepileptic drugs in utero. B vitamins for stroke prevention. [Full Text]. [, Bjork M, Riedel B, Spigset O, et al. The result may come in hours, however, one may need other follow-up tests (if the doctor feels). [, van Wijngaarden JP, Swart KM, Enneman AW, et al. Methotrexate (Rheumatrex, Trexall), used to treat cancer and autoimmune diseases, is a folate antagonist. Serum folate levels are The mixed findings from clinical trials, combined with evidence from laboratory and animal studies indicating that high folate status promotes tumor progression, suggest that folate might play dual roles in cancer risk, depending on the dosage and timing of the exposure. Centers for Disease Control and Prevention. [, Hooshmand B, Solomon A, Kareholt I, et al. Most observational studies conducted to date have shown positive associations between elevated homocysteine levels and the incidence of both Alzheimers disease and dementia [32,79,100-104]. Am J Clin Nutr 2003;77:658-62. JAMA 2004;291:565-75. r\a W+ My Dr said there's no problem with these results. Updated: Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. Before your visit, write down questions you want answered. It can also cause megaloblastic anemia. Hereof, how long does it take to correct folic acid deficiency? For folate deficiency anaemia - treatment is usually for 4 months. But if the cause of your folate deficiency anaemia does not change or go away, you may have to take folic acid for longer, possibly for the rest of your life. Several epidemiological studies have found inverse associations between high dietary folate intakes and the risk of colorectal adenoma and cancer [61-64]. Can anyone explain why? A secondary analysis of the study by Cole and colleagues [71] found that folic acid supplementation significantly increased the risk of prostate cancer [76] . 0000013144 00000 n I am now showing signs of damage to my liver. U.S. Department of Agriculture, Agricultural Research Service. Erythrocyte folate concentrations provide a longer-term measure of folate intakes; a concentration above 140 ng/mL indicates adequate folate status [2,3,7,9]. Antiepileptic drugs interact with folate and vitamin B12 serum levels. My father died due to the build up of iron in his heart. [, Green TJ, Liu Y, Dadgar S, et al. [, Viswanathan M, Treiman KA, Kish-Doto J, et al. 0000010880 00000 n 16(3):153-61. Questions about this possibility still remain, but the focus of concern has shifted to the potential for large amounts of folate to precipitate or exacerbate the anemia and cognitive symptoms associated with vitamin B12 deficiency [2,85,148-153]. [, Song Y, Manson JE, Lee IM, et al. In addition, some scientists have hypothesized that unmetabolized folic acid might be related to cognitive impairment among older adults [156]. We both had migraine, severe fatigue, and other dreadful debilitating symptoms. Am J Epidemiol 2013;178:1028-37. Canada Gazette 1998;132. 11th ed. Wang G, Mao JM, Wang X, Zhang FC. [, Morris MS, Jacques PF, Rosenberg IH,et al. J Formos Med Assoc. Pradyumna D Phatak, MBBS, MD is a member of the following medical societies: American Society of HematologyDisclosure: Received honoraria from Novartis for speaking and teaching. 206(3):218.e1-13. The FNB did not establish a UL for folate from food because high intakes of folate from food sources have not been reported to cause adverse effects [2]. Cochrane Database Syst Rev 2000:CD000951. Before entering the bloodstream, the enzyme dihydrofolate reductase reduces the monoglutamate form to THF and converts it to either methyl or formyl forms [1]. If the test is conducted on the blood plasma, a normal range for folate is 2 to 10 ng/mL and if the test is conducted on red blood cells, a normal range is 140 to 960 ng/mL. Conversely, a longitudinal, population-based cohort of 35,059 pregnant Danish women and their children found no association between periconceptional folic acid or multivitamin use and ASD [53]. J Alzheimers Dis 2012;29:133-49. The usual therapeutic dosage in adults and children (regard less of age) is up to 1 mg Consult with your healthcare professional before consuming a folate supplement when you are taking anticonvulsant medication. Washington, DC: Wiley-Blackwell; 2012:321-42. Pancreatic Elastase Stool Test Purpose, Procedure, Results, Normal Range, What is Cardiac Ablation? Mean dietary intakes of folate from foods range from 417 to 547 mcg DFE per day for children aged 219 [28]. [QxMD MEDLINE Link]. * DV = Daily Value. Blood tests show Folate >20.0 ng/mL and VIT B12 is 1378 pg/mL. [Also Read: Disease caused by vitamin and mineral deficiencies]. I would appreciate knowing what to ask the doctor about. JAMA 2015;313:1325-35. 1990 Apr. Several clinical trials have examined whether supplemental folic acid (sometimes in combination with other B-vitamins) reduces the risk of colorectal adenoma in individuals with or without a history of adenoma. For example: Your lab results may show the levels 12 and laboratory normal levels if higher than 5. Am J Clin Nutr 2014;100:1278-86. Serum gel tubes should be centrifuged within 2 hours of collection. However, in a subset of women with a low baseline dietary intake of B vitamins, supplementation significantly slowed the rate of cognitive decline. Share cases and questions with Physicians on Medscape consult. [QxMD MEDLINE Link]. If a person has a B12 deficiency, they may have excess folic acid as the folic acid remains in the body. 0000185047 00000 n Periconceptional use of folic acid might mitigate the potentially increased risk of ASD in children exposed to certain drugs and neurotoxins in utero [44-46]. Taking the right amount of folic acid before and during pregnancy helps prevent neural tube defects, Dongpeng Debao Commercial Center. Some, but not all, observational studies have shown associations between maternal use of folic acid and/or multivitamin supplements before and/or during pregnancy and lower risk of ASD in the womens offspring. Accessed: September 14, 2018. For folic acid, 1,000 mcg is equivalent to 1,667 mcg DFE because 0.6 mcg folic acid = 1 mcg DFE [11,164]. Please confirm that you would like to log out of Medscape. Pernicious anemia occurs when the your body doesn't make enough healthy red blood cells resulting from a vitamin B-12 deficiency, and a high folic acid level might hide the damaging effects of the deficiency by correcting the anemia caused by a vitamin B-12 deficiency, but doesn't correct the neurological damage that may also occur. The authors and editors of Medscape Reference also gratefully acknowledge the contributions of previous coauthors Subir Vij, MD, MPH and Waleed Siddiqi, MD to the development and writing of this article. Web3.9 20 ug/L Test Usage Folate deficiency is associated with three important disorders. 2009 Jul 24. JAMA. In folate deficiency, homocysteine levels are elevated and MMA levels are normal. Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G. 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Of damage to my liver high folic acid before and during pregnancy with the risk spontaneous!, homocysteine levels are normal showing signs of hemochromatosis the result may in...